What does PINK1 stand for
PINK1. Identifiers. Aliases. PINK1, BRPK, PARK6, PTEN induced putative kinase 1, PTEN induced kinase 1. PTEN-induced kinase 1 (PINK1) is a mitochondrial serine/threonine-protein kinase encoded by the PINK1 gene.
What does the PINK1 gene code for
Parkinson Disease 6, Autosomal Recessive Early-Onset, and Parkinson Disease 2, Autosomal Recessive Juvenile are two conditions linked to the protein-coding gene PINK1 (PTEN Induced Kinase 1).
What does Parkin protein do
Ubiquitin serves as a signal to move unwanted proteins into specialized cell structures called proteasomes, where the proteins are degraded. Parkin participates in the cell machinery that destroys (degrades) unneeded proteins by labeling damaged and surplus proteins with ubiquitin molecules.
Is synuclein alpha a protein
Mutations in the gene encoding -synuclein (SNCA) have been linked to familial Parkinson disease, and -synuclein is an unfolded protein that accumulates in Lewy bodies and Lewy neurites in Parkinson disease and other synucleinopathies.
What does OPA1 stand for
Optic Atrophy 1 and Optic Atrophy With Or Without Deafness, Ophthalmoplegia, Myopathy, Ataxia, and Neuropathy are diseases linked to the protein-coding gene OPA1 (OPA1 Mitochondrial Dynamin Like GTPase).
What is PARK2 gene
The Parkin protein, which is produced by the PARK2 gene and has as its primary function the regulation of mitophagy, works in conjunction with the PINK1 mitochondrial protein, which is a byproduct of another gene associated with autosomal recessive Parkinsons disease [6].
What is GBA gene
The beta-glucocerebrosidase enzyme, which is produced by the GBA gene, is active in lysosomes, which are internal cell structures that serve as recycling hubs.
How does MPTP cause Parkinsons
It has been used to study disease models in various animal studies. MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) is a prodrug to the neurotoxin MPP, which causes permanent symptoms of Parkinsons disease by destroying dopaminergic neurons in the substantia nigra of the brain.
What chromosome is LRRK2 on
Dardarin is a large protein that is encoded by the LRRK2 gene, which is located on chromosome 12p11.2-q13.1. Dardarin has several functional domains, including a leucine-rich repeat domain, WD40, renin-angiotensin system/guanosine triphosphatases, and kinase domains.
What chromosome is Park7 on
Park7 is a novel locus on chromosome 1p36 for autosomal recessive early-onset parkinsonism.
Who discovered Mitophagy
Margaret Reed Lewis and Warren Harmon Lewis were the first to describe the process of mitophagy more than a century ago.
What is the function of PINK1
Loss of PINK1 results in increased fission in mammalian mitochondria. PINK1 is a potential pro-fusion protein in mammals and a pro-fission protein in Drosophila.
What chromosome is PINK1 on
PINK1
Gene location (Human) | ||
---|---|---|
Chr. | Chromosome 1 (human) | |
Band | 1p36.12 | 20,633,458 bp |
20,651,511 bp |
What is SNCA gene
Alpha-synuclein is a small protein that is made thanks to the SNCA gene; it is found in large amounts in the brain and in smaller amounts in the heart, muscles, and other tissues.
What protein does PINK1 code for
PTEN induced putative kinase 1 is a protein that the PINK1 gene codes for, and it is present in every cell of the body with the highest concentrations in the heart, muscles, and testes.